کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
331276 | 1433646 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Glucocorticoid receptor variant and risk of dementia and white matter lesions Glucocorticoid receptor variant and risk of dementia and white matter lesions](/preview/png/331276.png)
ObjectiveElevated glucocorticoid levels are associated with dementia. A glucocorticoid receptor gene variant (ER22/23EK) is related to relative glucocorticoid resistance. We investigated whether the ER22/23EK allele is associated with dementia and structural brain abnormalities.MethodsThis study was performed in two prospective population-based cohort studies among elderly. The first study included 6034 participants who were screened for dementia (mean follow-up 5.8 years). The second study included 1011 elderly subjects with an MRI at baseline and follow-up. The ER22/23EK allele was assessed for association with dementia, cognitive function and white matter lesions.ResultsThe ER22/23EK allele was associated with a decreased risk of dementia. Among non-demented participants, ER22/23EK-carriers had a better performance on psychomotor speed tests than non-carriers. No differences were found in memory function between genotypes. In addition, both presence and progression of white matter lesions was lower in ER22/23EK-carriers. No association was found with brain atrophy on MRI.ConclusionsOur findings suggest a protective effect of the ER22/23EK allele on the risk of dementia and white matter lesions.
Journal: Neurobiology of Aging - Volume 29, Issue 5, May 2008, Pages 716–723