کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
331294 1433661 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI
چکیده انگلیسی

Hippocampus atrophy is a frequent finding in mild cognitive impairment (MCI), whereas diffusion-tensor-imaging (DTI) has demonstrated its value to detect subtle brain tissue changes in several neuropsychiatric diseases including MCI. To compare the diagnostic accuracy of both methods, high resolution MRI scans for hippocampus volumetry, and co-registered DTI-scans for ROI-based mean diffusivity (MD) and fractional anisotropy (FA) were carried out in 18 patients with amnestic MCI (7 females, age 67.3 ± 8.7 years, MMSE 25.2 ± 2.2) and 18 controls (age 66.9 ± 9.0 years, MMSE 28.7 ± 1.0). Diagnostic properties of normalized hippocampus volume (HV) and DTI measures with regard to MCI status were estimated by receiver operating characteristics (ROC) analyses and logistic regression. Parameters of the left hippocampus showed superior predictive power when compared to the right. At a specificity set to 80%, left HV had low sensitivity (50%); left hippocampal MD values revealed superior sensitivity (89%), similar to left hippocampal FA (78%). The results demonstrate higher sensitivity of DTI-derived left hippocampal parameters than volume measures in detecting subtle hippocampal abnormalities related to MCI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 28, Issue 3, March 2007, Pages 398–403
نویسندگان
, , , , , , ,