کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3314416 1211197 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Peg-interferon alone or combined with ribavirin in HCV cirrhosis with portal hypertension: A randomized controlled trial
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Peg-interferon alone or combined with ribavirin in HCV cirrhosis with portal hypertension: A randomized controlled trial
چکیده انگلیسی

Background/AimsRisks and benefits of antiviral therapy in HCV cirrhosis with portal hypertension are poorly known.MethodsWe performed a randomized controlled trial in 102 HCV patients with compensated cirrhosis and portal hypertension: 51 received 1 μg/kg/week of Pegylated-interferon α-2b and 51 Pegylated-interferon plus 800 mg/day of ribavirin up to 52 weeks.ResultsBy intention-to-treat analysis, five patients on monotherapy and eleven on combination therapy achieved a sustained virological response (9.8% vs. 21.6%, p = 0.06). The response was more frequent for genotypes 2 or 3 than genotype 1 (66.6% vs. 11.3%, p = 0.001). Genotype 1, who had low viral load at start of therapy, were HCV–RNA negative at 4 weeks, and were adherent to the scheduled therapy had a higher probability of sustained virological response. Patients with sustained virological response had less disease events compared to nonresponders (6.2% vs. 38.3%, p = 0.03 by log rank test) during follow-up.ConclusionsIn HCV cirrhosis with portal hypertension Peg-interferon plus ribavirin is a feasible treatment. Although the rate of viral eradication is modest, tailoring by genotype and early viral response allows to keep patients on treatment who are more likely to have viral eradication. Patients with viral eradication have fewer disease complications during follow-up.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 47, Issue 4, October 2007, Pages 484–491
نویسندگان
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