کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3314458 1211200 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death
چکیده انگلیسی

Background/AimsHigh serum ferritin and liver iron concentrations were found in some patients with NASH, suggesting a role for iron as a co-factor that aggravates liver injury. The aim of this study is to investigate the effects of parenteral iron in a rat model of NASH induced by a methionine choline deficient diet (MCDD).MethodsWistar rats were divided into 1 – Control, 2 – Iron (Fe), 3 – MCDD, 4 – MCDD&Fe groups. Iron dextran 100 mg/kg was administered intra-muscularly in groups 2 and 4. All rats were fed MCDD, Groups 1 and 2 were supplied with choline and methionine. Blood and tissue samples were obtained after 4 weeks.ResultsThe iron injection alone did not affect the liver whereas MCDD led to steatohepatitis. Iron worsened steatosis without any obvious effect on accompanying inflammation. It aggravated tissue injury by increasing apoptosis. Liver fibrosis was observed only in 3 out of 10 rats in the MCDD&Fe group.ConclusionsObservation of liver fibrosis only in the MCDD&Fe group suggests that iron induced increase in apoptosis contributes to the development of fibrosis at an earlier time than expected.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 47, Issue 6, December 2007, Pages 851–859
نویسندگان
, , , , , , , , , , , ,