کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3314916 1211227 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dynamics of the vascular profile of the finer branches of the biliary tree in normal and diseased human livers
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Dynamics of the vascular profile of the finer branches of the biliary tree in normal and diseased human livers
چکیده انگلیسی

Background/AimsResults of our previous studies supported the concept that in the human liver, the smallest ramification of the biliary tree, the bile ductules, might contain hepatic progenitor cells. An insufficient proliferative response and loss of bile ductules preceded bile duct loss whereas preservation of bile ductules mitigated bile duct loss.MethodsPresently we investigated the vascular profile of the bile ductules in diseased human livers and livers showing normal histological features as controls, using CD34, CK7 and αSMA antibodies in a double immunolabeling technique. VEGF-A expression was also studied.In control livers bile ductules traversed the boundaries of the portal tract into the lobule as ductular–vascular units, in a pattern outlining the classic hexagonal lobule, following the vascular septa. The latter are thought to be extensions of portal veins. In diseased states the two structures reacted in unison. Increased or decreased numbers of ductules were consistently accompanied by similar changes of accompanying microvessels. Increased numbers of ductules and microvessels were paralleled by increased ductular expression of VEGF-A.ResultsOur data support the concept that the smallest branches of the biliary tree might have their own vascular supply and that the ductules might in turn maintain their vasculature during regenerative processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 45, Issue 3, September 2006, Pages 393–400
نویسندگان
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