کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3315446 1211260 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver
چکیده انگلیسی

Background/AimsHepatitis B virus transgenic mice (HBV-Tg mice) have been widely used as animal models in the study of pathogenesis and control of hepatitis B. It is important for the evaluation of such animal models to define the physiological differences between HBV-Tg and wild-type mice. The aim of this research was to investigate whether the integrated system biology approach that combines proteomics and metabonomics describes the physiological changes and provides new insights into the pathogenesis of the early stages of HBV infection.MethodsIn this study the protein and metabolite profiles of the liver were established based on two-dimensional electrophoresis and HPLC/MS analysis.ResultsSeveral protein molecules, whose expression was altered in HBV-Tg mouse liver, were identified including protective enzymes against oxidative stress and regulatory proteins related to lipid metabolism. Metabonomics confirmed the potential derangement of lipid metabolism by discovering the intermediate and the final products of lipid metabolism that were markedly changed in transgenic mice.ConclusionsThis study demonstrated that HBV antigens could impair host cell lipid metabolism and induce modest oxidative stress in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 48, Issue 1, January 2008, Pages 12–19
نویسندگان
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