کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3333697 | 1213334 | 2011 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma: Where Are We Now and Which Way Should We Go?
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
هماتولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma: Where Are We Now and Which Way Should We Go? Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma: Where Are We Now and Which Way Should We Go?](/preview/png/3333697.png)
چکیده انگلیسی
Despite the use of intensive chemotherapy regimens with or without autologous stem cell transplant (auto-SCT) support, the clinical course of mantle cell lymphoma (MCL) remains characterized by iterative relapses and is still an incurable disease. The impact of allogeneic stem cell transplantation (allo-SCT) in MCL emerged in the late 1990s when it was shown that myeloablative allo-SCT could potentially cure some relapsed/refractory MCL patients. This curative impact is sustained by a graft-versus-disease (GVD-MCL) effect. However, toxicity and mortality following myeloablative allo-SCT are too high and have limited its use for patients aged under 65 years at diagnosis. Reduced-intensity conditioning regimens (RIC-allo) entail lower toxicity and reduced transplant-related mortality (TRM), making allogeneic transplant a valid option for a larger MCL population. At present, RIC-allo should be considered a valid therapeutic option for relapsed MCL patients and innovative therapeutic strategies including RIC-allo need to be investigated. Herein, the role of GVD-MCL and place of allo-SCT in MCL is discussed, taking into account the most recent literature, and several ways to improve RIC-allo in MCL that deserve to be explored are presented.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Hematology - Volume 48, Issue 3, July 2011, Pages 227-239
Journal: Seminars in Hematology - Volume 48, Issue 3, July 2011, Pages 227-239
نویسندگان
Steven Le Gouill, Mohamad Mohty, Thierry Guillaume, Thomas Gastinne, Philippe Moreau,