کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3334089 | 1213364 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Relevance of Iron in Erythropoietin-Stimulated Erythropoiesis
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
هماتولوژی
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چکیده انگلیسی
Several clinical models have generated insight into the relationship between erythropoietin (EPO), iron, and erythropoiesis. Patients with chronic hemolytic anemias or hemochromatosis can increase erythropoiesis six- to eightfold over basal rates, whereas patients with blood loss, such as those donating autologous blood, can increase erythropoiesis only two- to fourfold over basal levels, even with pharmacologic doses of recombinant human EPO. A substantial limitation to the dose/response relationship between EPO therapy and the erythropoietic response is iron-restricted erythropoiesis, even in the presence of storage iron. Novel approaches to iron supplementation therapy when erythropoietic agents are used are indicated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Hematology - Volume 43, Supplement 6, October 2006, Pages S3–S8
Journal: Seminars in Hematology - Volume 43, Supplement 6, October 2006, Pages S3–S8
نویسندگان
Lawrence Tim Goodnough,