کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3334159 1213369 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Renal Disease and Anemia in the Elderly
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Renal Disease and Anemia in the Elderly
چکیده انگلیسی
As individuals age, the incidence of both renal insufficiency and anemia increases. Some of the changes in renal function can be traced to age-related alterations in the renal vasculature that may dissociate renal blood flow from glomerular filtration. In addition, there appear to be paradoxical changes in renal production of erythropoietin (Epo), in that Epo levels actually increase over time with aging, suggesting that the erythroid marrow may become less sensitive to Epo stimulation. These factors, together with the confounding effects of possible nutritional deficits and the disproportionate effect of early-stage diabetes mellitus on renal endocrine function and Epo production, all can contribute to anemia in the elderly. As anemia is an independent predictor of poor outcomes with many diseases and at any age, recognizing and correcting the underlying cause of the anemia is an important aspect of medically managing the elderly patient.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Hematology - Volume 45, Issue 4, October 2008, Pages 235-241
نویسندگان
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