کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3337649 1213810 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Collagen proportionate area of liver tissue determined by digital image analysis in patients with HBV-related decompensated cirrhosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کبدشناسی
پیش نمایش صفحه اول مقاله
Collagen proportionate area of liver tissue determined by digital image analysis in patients with HBV-related decompensated cirrhosis
چکیده انگلیسی

BackgroundThe accurate assessment of the degree of hepatic fibrosis plays a critical role in guiding the diagnosis, treatment and prognostic assessment of chronic liver diseases. Liver biopsy is currently the most reliable method to evaluate the severity of hepatic fibrosis. However, liver biopsy is an invasive procedure associated with morbidity and mortality, and has several limitations in patients with decompensated cirrhosis. There is no report on the collagen proportionate area (CPA) of liver tissue in the decompensated stage of cirrhosis. This study aimed to determine the CPA of resected liver tissue samples from patients with HBV-related decompensated cirrhosis using digital image analysis, and to analyze the relationship between the CPA and liver functional reserve.MethodsFifty-three resected liver tissue samples from liver transplant patients with chronic hepatitis B-induced decompensated cirrhosis were stained with Masson's trichrome, and the CPA in these samples was quantitatively determined using digital image analysis. The values ofrelevant liver function just before liver transplantation, the CPA in liver tissue, and their correlation were analyzed.ResultsThe mean CPA at the decompensated stage of cirrhosis was 35.93±14.42% (11.24%–63.41%). The correlation coefficients of the CPA with a model for end-stage liver disease score, serum total bilirubin and international standard ratio of prothrombin B were 0.553, 0.519 and 0.533, respectively (P<0.001). With increasing CPA values, the three indices reflecting liver functional reserve also changed significantly.ConclusionsThe degree of fibrosis may be correlated with the functional reserve. With the advancement of fibrosis, the liver functional reserve is attenuated accordingly.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hepatobiliary & Pancreatic Diseases International - Volume 10, Issue 5, October 2011, Pages 497-501