New onset diabetes after transplantation (NODAT): Analysis of pre-transplant risk factors in renal allograft recipients

BackgroundOccurrence of new onset diabetes after transplant (NODAT) has major impact on patient and graft survival, and cardiovascular mortality.MethodsIn this retrospective study, among all renal transplant recipients who followed-up at our center during the period of January 1998 to April 2012, the development of NODAT was assessed by reviewing case records. Characteristics of patients with NODAT were compared with the patients who did not develop post-transplant diabetes.ResultsTotal 68 non-diabetic renal transplant recipients were included in analysis. Emergence of NODAT was observed in 13 (19.12%) recipients, with mean duration of onset at 52.73 ± 49.57 months post-transplant. Development of NODAT was significantly associated with; age of ≥45 years at transplant time (P 0.029, odds ratio 4.38), pre-transplant weight (P 0.031), presence of ADPKD (P 0.020, odds ratio 16.20), positive family history of diabetes (P 0.009, odds ratio 5.96), pre-transplant hypercholesterolemia (P 0.029, odds ratio 4.38), and pre-transplant hypertriglyceridemia (P 0.023, odds ratio 5.03). Risk of development of diabetes was not related to type of calcineurin inhibitor used.ConclusionNODAT is common in our renal transplant patients. Risk of development of post-transplant diabetes was more closely related to traditional risk factors and was not influenced by immunosuppressive therapy.