Double drug abuse in renal transplant patient - A case report

In Renal transplant patients prevalence of gingival enlargement due to cyclosporine along with calcium channel blockers are increasing, as calcium channel blockers are drug of choice in cases with cyclosporine induced renal hypertension. As the treatment part in most of the cases to reduce gingival overgrowth, tacrolimus substitution to cyclosporine, is sufficient. But, as per present case report, patient is intolerant to tacrolimus. So, periodontal therapy is an only alternative to this patient. Thus, trying to understand and correlate internal mechanism of action of cyclosporine & amlodipine, with histopathologic & clinical picture of gingival enlargement; and decide corrective periodontal treatment is a humble aim of present case report, but the present case report invites lots of further research work in this direction. A case is presented to illustrate adverse effects of both the drugs in under treatment renal transplant patient clinically as well as histopathologically & its periodontal management.