Giant Papillary Conjunctivitis

Contact lens wearers with giant papillary conjunctivitis report a variety of symptoms, including decreased lens tolerance, increased lens awareness, excessive lens movement, increased mucus production associated with ocular irritation, redness, burning, and itching. This article reviews the clinical signs and symptoms related to contact lens–induced giant papillary conjunctivitis. The epidemiology, histology, and pathophysiology are reviewed in depth. A variety of treatment strategies are discussed that enable patients with this condition to remain in contact lenses.