Protective effect of rutin in attenuation of collagen-induced arthritis in Wistar rat by inhibiting inflammation and oxidative stress

These data confirm that erosive destruction of the joint cartilage in CIA is due to free radicals released by activated neutrophils. The beneficial effect of rutin may be due to its antioxidant and anti-inflammatory activity. This study indicates that the administration of rutin might have potential value in the treatment of rheumatoid arthritis.