کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3440434 1595018 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Meta-analysis of first trimester Down syndrome screening studies: free β-human chorionic gonadotropin significantly outperforms intact human chorionic gonadotropin in a multimarker protocol
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Meta-analysis of first trimester Down syndrome screening studies: free β-human chorionic gonadotropin significantly outperforms intact human chorionic gonadotropin in a multimarker protocol
چکیده انگلیسی

ObjectiveThe purpose of this study was to compare free β and intact human chorionic gonadotropin in first trimester screening with pregnancy-associated plasma protein-A and nuchal translucency.Study DesignA Monte Carlo simulation trial was conducted based on a literature review of the PUBMED database (1966 to November 2005).ResultsIn younger patients (<35 years), detection of Down syndrome increased by 4, 5, 6, and 7 percentage points when free β was added to pregnancy-associated plasma protein-A and nuchal translucency compared with 0, 0, 2, and 4 percentage points for intact human chorionic gonadotropin at 9-12 weeks’ gestation, respectively. In advanced maternal age patients (≥35), inclusion of free β-human chorionic gonadotropin reduced the false-positive rate by 2.5, 3.1, 3.8, and 4.4 percentage points compared with 0.1, 0.3, 1.0, and 2.2 percentage points for intact human chorionic gonadotropin at 9-12 weeks, respectively.ConclusionThe results of our analysis suggest that in a first-trimester Down syndrome screening protocol free β-human chorionic gonadotropin achieves higher sensitivity and lower false-positive results than intact human chorionic gonadotropin . Moreover, intact human chorionic gonadotropin does not add substantially to screening performance until the end of the first trimester.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Obstetrics and Gynecology - Volume 196, Issue 3, March 2007, Pages 198–205
نویسندگان
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