کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3440754 1595024 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maternal N-acetylcysteine suppresses fetal inflammatory cytokine responses to maternal lipopolysaccharide
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Maternal N-acetylcysteine suppresses fetal inflammatory cytokine responses to maternal lipopolysaccharide
چکیده انگلیسی

ObjectiveEvidence suggests that maternal infections may induce fetal inflammatory responses. Because cytokine actions may be mediated by oxidative stress, we determined whether N-acetylcysteine, an antioxidant, can blunt fetal inflammatory responses to maternal lipopolysaccharide.Study designSprague Dawley near-term rats (n = 16) received intraperitoneal lipopolysaccharide (100 μg/kg) at 30 minutes and saline solution or N-acetylcysteine (300 mg/kg) at 150 minutes. An additional group received N-acetylcysteine before and after lipopolysaccharide administration. At 6 hours, rats were killed, and fetal and maternal blood cytokines were determined.ResultsAfter maternal lipopolysaccharide administration, fetal blood interleukin-6 markedly increased (3 ± 2 to 1265 ± 574 pg/mL); N-acetylcysteine that was given before or before and after lipopolysaccharide administration reduced fetal interleukin-6 response to control levels. A similar trend was observed for interleukin-1β. No effect of N-acetylcysteine on fetal interleukin-10 levels was observed.ConclusionMaternal N-acetylcysteine inhibits fetal cytokine responses to maternal lipopolysaccharide, even when given 2 hours after lipopolysaccharide injection. These results suggest that N-acetylcysteine may protect the fetus from sequelae of maternal inflammation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Obstetrics and Gynecology - Volume 195, Issue 4, October 2006, Pages 1053–1057
نویسندگان
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