کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3442233 | 1595034 | 2006 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Nevirapine toxicity in a cohort of HIV-1–infected pregnant women Nevirapine toxicity in a cohort of HIV-1–infected pregnant women](/preview/png/3442233.png)
ObjectiveThe purpose of this study was to complete an evaluation of nevirapine (NVP) toxicity in a cohort of HIV+ pregnant women.Study designThis was a retrospective study of 611 women followed from January 1996 to December 2003. All women who used NVP for >7 days were included. Multivariate logistic regression was used to test independent association of CD4 and hepatitis C virus (HCV) infection related to the outcome of toxic effects of NVP.ResultsOne hundred ninety-seven women were exposed to NVP for >7 days, and toxicity occurred in 11 (5.6%), leading to drug discontinuation in 7 patients. One case of Stevens-Johnson syndrome occurred. No serious liver toxicity occurred except for 1 grade 4 cholestasis. Median CD4 was 344 in women without toxicities and 298 in women with toxicities. HCV was the only significant factor associated to toxicity by logistic regression (odds ratio [OR] 15.61, P = .001).ConclusionNVP toxicities occurred in a very small fraction of patients and were not associated with fatalities.
Journal: American Journal of Obstetrics and Gynecology - Volume 194, Issue 1, January 2006, Pages 199–202