کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3442448 1595021 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hypervolemia of pregnancy is not maintained in mice chronically overexpressing angiotensinogen
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Hypervolemia of pregnancy is not maintained in mice chronically overexpressing angiotensinogen
چکیده انگلیسی

ObjectiveWomen who develop pre-eclampsia show significantly less hypervolemia of pregnancy, compared with controls. We have shown that chronically elevated angiotensinogen expression increases a woman's risk of developing pre-eclampsia. Our objective was to determine whether increased angiotensinogen expression is sufficient to cause failed hypervolemia.Study designTo isolate the effects of elevated angiotensinogen expression, we studied transgenic mice with either 2 or 3 copies of the murine angiotensinogen gene. Plasma volume was measured by Evans blue dye dilution, and kidney sections were immunostained for angiotensinogen and renin.ResultsThree-copy mice failed to maintain hypervolemia after midgestation (P < .01) and failed to up-regulate renin expression in the distal nephron, compared with 2-copy controls. Intrarenal angiotensinogen was up-regulated during pregnancy in both genotypes.ConclusionChronically elevated angiotensinogen expression is sufficient to cause failed hypervolemia of pregnancy. Whether this observation is related to failed up-regulation of distal tubule renin expression requires further study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Obstetrics and Gynecology - Volume 195, Issue 6, December 2006, Pages 1700–1706
نویسندگان
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