کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3442861 | 1595043 | 2005 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prospective first-trimester screening for trisomy 21 in 30,564 pregnancies Prospective first-trimester screening for trisomy 21 in 30,564 pregnancies](/preview/png/3442861.png)
ObjectiveThis study was undertaken to evaluate the performance of a 1-stop clinic for first-trimester assessment of risk (OSCAR) for trisomy 21 by a combination of maternal age, fetal nuchal translucency (NT) thickness, and maternal serum-free ß- human chorionic gonadotrophin (hCG) and pregnancy-associated plasma protein-A (PAPP-A).Study designOSCAR was carried out in 30,564 pregnancies at 11 to 13+6 weeks. Patient-specific risks for trisomy 21 and detection and false-positive rates were calculated.ResultsThe median maternal age was 34 (range 15-49) years. Chromosomal abnormalities were identified in 330 pregnancies, including 196 cases of trisomy 21. The estimated risk for trisomy 21 was 1 in 300 or greater in 7.5% of the normal pregnancies, in 93.4% of those with trisomy 21 and in 88.8% of those with other chromosomal defects.ConclusionThe most effective method of screening for chromosomal defects is by first-trimester fetal NT and maternal serum biochemistry.
Journal: American Journal of Obstetrics and Gynecology - Volume 192, Issue 6, June 2005, Pages 1761–1767