کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3443897 | 1595244 | 2015 | 4 صفحه PDF | دانلود رایگان |
• We examined the validity of a claims-based algorithm to identify CRC recurrence.
• We determined the extent to which recurrence misclassification affects survival.
• Secondary malignancy codes yielded moderate sensitivity and high specificity.
• Identifying recurrence in CRC patients using claims data is feasible.
• Addressing misclassification is important when using claims-based algorithms.
PurposeTo examine the validity of claims data to identify colorectal cancer (CRC) recurrence and determine the extent to which misclassification of recurrence status affects estimates of its association with overall survival in a population-based administrative database.MethodsWe calculated the accuracy of claims data relative to medical records from one large tertiary hospital to identify CRC recurrence. We estimated the effect of misclassifying recurrence on survival by applying these findings to the linked Surveillance, Epidemiology, and End Results–Medicare data.ResultsOf 174 eligible CRC patients identified through medical records, 32 (18.4%) had a recurrence. A claims-based algorithm of secondary malignancy codes yielded a sensitivity of 81% and specificity of 99% for identifying recurrence. Agreement between data sources was almost perfect (kappa: 0.86). In a model unadjusted for misclassification, CRC patients with recurrence were 3.04 times (95% confidence interval: 2.92–3.17) more likely to die of any cause than those without recurrence. In the corrected model, CRC patients with recurrence were 3.47 times (95% confidence interval: 3.06–4.14) more likely to die than those without recurrence.ConclusionsIdentifying recurrence in CRC patients using claims data is feasible with moderate sensitivity and high specificity. Future studies can use this algorithm with Surveillance, Epidemiology, and End Results–Medicare data to study treatment patterns and outcomes of CRC patients with recurrence.
Journal: Annals of Epidemiology - Volume 25, Issue 4, April 2015, Pages 297–300