Association Between Birthweight and Cognitive Function in Middle Age: The Atherosclerosis Risk in Communities Study

PurposeWe aimed to examine the relationship of birthweight to cognitive performance in middle aged participants of the Atherosclerosis Risk in Communities Study (ARIC).MethodsCognitive function, assessed by means of three neuropsychological tests—the Delayed Word Recall Test (DWR), the Digit Symbol Subtest of the Wechsler Adult Intelligence Scale-Revised (DSS/WAIS-R), and the Word Fluency (WF) Test, was evaluated in relation to birthweight, as recalled through standardized interviews, by the use of data from the second and fourth follow-up visits of the Atherosclerosis Risk in Communities study cohort (1990−1992 and 1996−1998, respectively). Overall, 6785 participants satisfied the inclusion criteria and were included in the analysis.ResultsAfter adjusting for adult sociodemographic factors, childhood socioeconomic environment and parental risk factors, and adult anthropometric, health status-related. and behavioral variables, we observed linear trends for the relationship of birthweight to WF scores, although the trend was statistically significant only for those reporting exact birthweights (p for trend = .004). For the other cognitive test results, results were either null or inconsistent with the a priori hypotheses.ConclusionsExcept for WF in those reporting exact birthweights, our study does not support the notion that birthweight influences cognitive function in adults.