کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3444881 1595324 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Smoking and the Risk of Age-related Macular Degeneration: A Meta-Analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Smoking and the Risk of Age-related Macular Degeneration: A Meta-Analysis
چکیده انگلیسی

PurposeSome studies were undertaken to evaluate the association between cigarette smoking and age-related macular degeneration (AMD). This meta-analysis summarized the risk estimate of smoking and AMD and provided robust evidence for the association.MethodsRelevant studies were identified by searching PubMed and MEDLINE (from 1966 to June 2007) and reviewing the reference lists of key articles. The summary relative risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI) were calculated. Study-specific risk estimates were pooled using a random-effects model.ResultsFive prospective cohort and eight case-control studies met our inclusion criteria. Ever smoking was statistically significant associated with increased risk of AMD among cohort studies (RR, 1.61; 95% CI, 1.01–2.57) or case-control studies (RR, 1.76; 95% CI, 1.56–1.99). Current smokers were at higher risk of AMD than past smokers. Both geographic atrophy (GA) and neovascular AMD (NV) are subtypes of AMD. A significant relationship was found between smoking and GA risk. Smoking increased the risk of NV, with marginal nonsignificance (RR, 1.47; 95% CI, 0.92–2.37) in cohort studies and significance in case-control studies (RR, 1.96; 95% CI, 1.69–2.27).ConclusionsThis meta-analysis indicated smoking, especially current smoking, was significantly associated with increased risks of AMD and its subtypes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Epidemiology - Volume 18, Issue 8, August 2008, Pages 647–656
نویسندگان
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