کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3445334 1595306 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-Control Study
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-Control Study
چکیده انگلیسی

PurposeTo investigate risk factors that may be linked to pancreatic cancer.MethodsWe designed a multicenter population-based case–control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland.ResultsAfter adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23 − 9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18 − 74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60 − 2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56 − 12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50 − 0.82).ConclusionsPatients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Epidemiology - Volume 20, Issue 2, February 2010, Pages 92–98
نویسندگان
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