کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3445379 1595322 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Birth-Cohort Patterns of Mortality From Ulcerative Colitis and Peptic Ulcer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Birth-Cohort Patterns of Mortality From Ulcerative Colitis and Peptic Ulcer
چکیده انگلیسی

PurposeThe aim was to follow the time trends of mortality from ulcerative colitis and compare them with those of gastric and duodenal ulcer.MethodsMortality data from 21 different countries between 1941 and 2004 were analyzed. The age-specific death rates of each individual country, as well as the average age-specific rates of all countries, were plotted against the periods of birth and death.ResultsThe average trends of mortality from ulcerative colitis, gastric and duodenal ulcer reveal distinctive and unique birth-cohort patterns of all three diseases. Similar to both types of peptic ulcer, the risk of developing ulcerative colitis started to rise in successive generations born during the second half of the 19th century. It peaked shortly before the turn of the century and has continued to decline since then. The rise and fall in the occurrence of ulcerative colitis preceded those of both ulcer types.ConclusionThe birth-cohort pattern indicates that exposure to the relevant risk factors of ulcerative colitis occurs during early life. As the model of H. pylori and its associated birth-cohort patterns of gastric and duodenal ulcer suggest, an enteric infection provides a possible explanation for such temporal trends of ulcerative colitis as well.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Epidemiology - Volume 18, Issue 10, October 2008, Pages 813–819
نویسندگان
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