Improved Immune Function with Donor B-cell Infusion after Semi-Allogeneic Bone Marrow Transplantation in Mice

Our data document the feasibility of administering B-cell therapy post-allogeneic BMT to improve recovery of the humeral arm of the immune system while avoiding GVHD. Furthermore, post-transplant B-cell administration may have an important impact as an alternative to IV immunoglobulin infusions.