Expression of Cyclooxygenase-2 and Vascular Endothelial Growth Factor-C Correlates with Lymphangiogenesis and Lymphatic Invasion in Human Gastric Cancer

Our data suggest that the expression of COX-2 correlates with VEGF-C expression and both of them correlate with the presence of lymphatic invasion and prognosis in gastric cancer. COX-2-mediated VEGF-C overexpression might promote lymphatic invasion via lymphangiogenesis pathway in patients with gastric cancer.