کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3447460 | 1595529 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Analysis of the Sodium Iodide Symporter Expression in Histological Slides from a Nodular Goiter
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Analysis of the Sodium Iodide Symporter Expression in Histological Slides from a Nodular Goiter Analysis of the Sodium Iodide Symporter Expression in Histological Slides from a Nodular Goiter](/preview/png/3447460.png)
چکیده انگلیسی
Our data indicate that NIS protein participates in the development of hyperthyroidism in the course of a nodular goiter. We confirm that the functional state of a nodular goiter is determined by NIS expression in nodules, not in collateral parenchyma. The low metabolism of cold nodules does not simply result from decreased level of NIS protein or its defective targeting to the cell membrane. The observation of NIS in the cell cytoplasm of hot nodules seems to indicate that the intracellular localization of NIS does not determine loss of its activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Medical Research - Volume 38, Issue 2, February 2007, Pages 219-226
Journal: Archives of Medical Research - Volume 38, Issue 2, February 2007, Pages 219-226
نویسندگان
Anhelli Syrenicz, MaÅgorzata Wolny, Andrzej Kram, Krzysztof Sworczak, MaÅgorzata Syrenicz, Barbara Garanty-Bogacka, MieczysÅaw Walczak,