کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3451758 | 1595800 | 2006 | 10 صفحه PDF | دانلود رایگان |

Giacino JT, Hirsch J, Schiff N, Laureys S. Functional neuroimaging applications for assessment and rehabilitation planning in patients with disorders of consciousness.ObjectiveTo describe the theoretic framework, design, and potential clinical applications of functional neuroimaging protocols in patients with disorders of consciousness.Data SourcesRecent published literature and authors’ own work.Study SelectionStudies using functional neuroimaging techniques to investigate cognitive processing in patients diagnosed with vegetative and minimally conscious state.Data ExtractionNot applicable.Data SynthesisPositron-emission tomography activation studies suggest that the vegetative state represents a global disconnection syndrome in which higher order association cortices are functionally disconnected from primary cortical areas. In contrast, patterns of activation in functional magnetic resonance imaging studies of patients in the minimally conscious state show preservation of large-scale cortical networks associated with language and visual processing.ConclusionsNovel applications of functional neuroimaging in patients with disorders of consciousness may aid in differential diagnosis, prognostic assessment and identification of pathophysiologic mechanisms. Improvements in patient characterization may, in turn, provide new opportunities for restoration of function through interventional neuromodulation.
Journal: Archives of Physical Medicine and Rehabilitation - Volume 87, Issue 12, Supplement, December 2006, Pages 67–76