Hepatoprotective mechanism of lycorine against carbon tetrachloride induced toxicity in swiss albino mice – A proteomic approach

ObjectiveTo investigate the differential of protein expression in CCl4 induced mice treated with lycorine.MethodsThe present study was carried out to identify the differentially expressed protein in carbon tetrachloride (CCl4) induced oxidative stress mice treated with lycorine (5 mg/kg. bw) using 2D gel and MALDI-TOF.ResultsWe observed many kinds of differentially expressed protein in experimental liver. Among these, three are much differently expressed protein which is identified as ATP synthase, regucalcin and HSP60; these proteins are involved in the ATP synthesis, calcium regulation and rescue the integrity cellular proteins respectively.ConclusionsThis investigation provided a molecular mechanism of the lycorine during CCl4 induced oxidative stress in mice liver.