Effect of ethanolic seed extract of Caesalpinia bonducella pregnant female albino rats

ObjectiveIn the present study, an attempt has been made to investigate the effect of ethanolic seed extract of Caesalpinia bonducella(C. bonducella) on fertility in female Wistar albino rats.MethodsPregnant rats were randomized into two groups containing eight animals in each group. Control group rats were orally administered with 1 mL/100g b.wt of distilled water while rats in second group received 300mg/kg of the seed extract from gestation day 1-7, once daily. The animals were sacrificed twenty four hours after the last dose on gestation day 12.ResultsA significant reduction in implantation index and a contrasting significant increase in resorption index, pre-implantation and post-implantation loss was recorded in the seed extract treated rats. Progesterone level declined significantly in rats treated with seed extract. O vary revealed degenerated corpora lutea in treated rats. The embryos were noticed with craniofacial deformities in extract treated group.ConclusionsThe results obtained in this study suggest that the seeds of C. bonducella possess antifertility activity probably due to its antiprogesterogenic hormonal properties that can modulate the reproductive function of the experimental rats.