Hypoglycemic activity of methanolic leaf extract of Blumea lacera in Swiss-albino mice

ObjectiveTo estimate the hypoglycemic activity of Blumea lacera (B. lacera) leaf methanol extract.MethodsA study was undertaken for preliminary exploration of hypoglycemic activity via oral glucose tolerance test. B. lacera leaves were dried under shaded sunlight, milled and then macerated in methanol. Glibenclamide was used as reference drug, and 50-400 mg/kg leaf extract was administered orally to four test groups.ResultsTreatment of leaf extract on glucose loaded hypoglycemic mice lead to significant (P<0.0001) reduction of the blood glucose levels in a dose dependent manner.ConclusionsThe result suggests that methanolic leaf extract of B. lacera possesses anti-diabetic properties, and its use as ethnomedicine for treatment of diabetes.