The importance of eosinophil, platelet and dendritic cell in asthma

Asthma is a syndrome of variable airflow obstruction. It is characterized pathologically by bronchial inflammation and remodeling changes. Eosinophil infiltrate in asthma and a relationship between the degree of eosinophil infiltration in airways and severity of asthma has been suggested. Eosinophil has antigen-presenting cells and main role in allergic asthma. Platelets in inflammatory response is very important. It has also been shown that enzymes released by activated platelets play a direct role in the chronic inflammatory events that lead to airway remodeling in asthma. Dendritic cells (DCs) acquire antigen in the airways and then migrate to the draining lymph node where the cells mature and initiate T cell responses. Allergen challenge induces simultaneous increases in the number of DCs in the lungs. Because DCs are crucial in mounting immune responses during ongoing inflammation in the lung and balance of the allergic immune response.