کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3454410 1595966 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced pharmacokinetics of omeprazole when formulated as gastroretentive microspheres along with piperine
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Enhanced pharmacokinetics of omeprazole when formulated as gastroretentive microspheres along with piperine
چکیده انگلیسی

ObjectiveTo investigate the formulation of gastroretentive microspheres of omeprazole along with piperine and estimate the pharmacokinetic parameters in comparison with omeprazole alone.MethodsIn our present investigation, gastroretentive microspheres of omeprazole were prepared with the inclusion of piperine. Pharmacokinetic parameters like Cmax, Tmax and area under curve were estimated by administering the prepared microspheres to rabbits and the results were compared with omeprazole alone.ResultsThere was a significant increase in area under curve from 3.441±1.093 mg·h/mL to 14.422±0.708 mg·h/mL along with an increase in Cmax.ConclusionsThis clearly shows the increased absorption and decreased metabolism of omeprazole when administered along with piperine as gastroretentive microspheres.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Disease - Volume 4, Supplement 1, 2014, Pages S129-S133