A pharmacological evaluation of antidiarrhoeal activity of leaves extract of Murraya koenigii in experimentally induced diarrhoea in rats

ObjectiveTo evaluate anti-diarrhoeal activity of aqueous and alcoholic extract of the leaves of Murraya koenigii (M. koenigii)by using models of castor oil induced diarrhoea, charcoal meal test and PGE2 induced diarrhoea.MethodsAlcoholic extract (400 mg/kg) and aqueous extract (200 mg/kg) of leaves of Murraya koenigii were used with loperamide as standard. Albino Wistar rats of both sexes weighing between 150–250 g were used for the anti-diarrhoeal activity.ResultsThe result suggested that it could act centrally and inhibit the PGE2 to give anti-diarrhoeal effects. Result of charcoal meal test also suggested its anti-muscarnic activity.ConclusionsThese findings indicate that aqueous extract of the leaves of M. koenigii displays good anti-diarrhoeal activity, corroborating the folk use of M. koenigii preparations and contributing for its pharmacological validation.