کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3454678 1595980 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro, in vivo evaluation of inter polymer complexes between carboxymethyl fenugreek gum and chitosan or carboxymethyl guar gum and chitosan for colon delivery of tamoxifen
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
In vitro, in vivo evaluation of inter polymer complexes between carboxymethyl fenugreek gum and chitosan or carboxymethyl guar gum and chitosan for colon delivery of tamoxifen
چکیده انگلیسی

ObjectiveTo develop colon targeted tamoxifen tablets employing interpolymer complexes (IPC) between carboxymethyl fenugreek gum (CMF) and chitosan (CH) or carboxymethyl guar gum (CMG) and CH.MethodsIPC between CMF and CH or CMG or CH was obtained as a result of reaction between negatively charged -COO− group of CMF or CMG and positively charged -NH3+ group of CH. These interactions were characterized by FTIR spectroscopy. The core tablets were coated with various ratios of CMF: CH and CMG: CH IPC solutions. The coated tablets were subjected to in vitro dissolution studies in the presence or absence rat cecal contents. The selected coated tablets were evaluated for their pharmacokinetic behavior by oral administration to rats.ResultsThe tablets coated with CMF: CH 40:60 and CMG: CH 50:50 were capable of protecting drug release in pH 1.2 (stomach) and pH 7.4 (small intestine) and releasing, respectively, 91% and 94% tamoxifen in pH 6.8 in the presence of rat cecal contents. The oral administration of these tablets to rats showed a tmax of 10 hrs as compared to 2 hrs in case of uncoated tablets.ConclusionsThe tablets coated with CMF-CH ratio of 40:60 or CMG-CH ratio of 50:50 were able to protect drug release in stomach and small intestine and deliver tamoxifen after the tablets reached colon.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Disease - Volume 2, Supplement 1, 2012, Pages S202-S207