Protective effect of morin on lipid peroxidation and lipid profile in ammonium chloride–induced hyperammonemic rats

ObjectiveTo evaluated the protective effects of morin (3, 5, 7, 2′, 4′-pentahydroxyflavone) on lipid peroxidation and lipid levels during ammonium chloride (AC) induced hyperammonemia in experimental rats.MethodsThirty two male albino Wistar rats, which are weighing between 180–200 g were used for the study. The hyperammonemia was induced by administration of 100 mg/kg body weight (i.p.) thrice in a week of AC for 8 weeks. Rats were treated with morin at dose (30 mg/kg body weight) via intragastric intubations together with AC. At the end of experimental duration, blood ammonia, plasma urea, lipid peroxidation indices [thiobarbituric acid reactive substances, hydroperoxides and lipid levels (cholesterol, triglycerides, free fatty acids and phospholipids)] in serum and tissues were analysed to evaluate the antiperoxidative and antilipidemic effects of morin.ResultsAmmonia, urea, lipid peroxidative indices and lipid levels were significantly increased in AC administered group. Morin treatment resulted in positive modulation of ammonia, urea, lipid peroxidative indices and lipid levels. Morin administration to normal rats did not exhibit any significant changes in any of the parameters studied.ConclusionsIt can be concluded that the beneficial effect of morin on ammonia, urea, lipid peroxidative indices and lipid levels could be due to its antioxidant property.