CETP polymorphisms confer genetic contribution to centenarians of Hainan, south of China

ObjectiveIn this paper, we will discuss if the CETP polymorphism contributes to the centenarians in Hainan island.MethodsWe tested the TaqIB and I405V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package (Version 19.0).ResultsOur data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P < 0.001. Further analysis implied that genotypes B1B1 (P < 0.001, OR = 0.148, 95% CI = 0.095–0.230) and VV (P < 0.001 and OR = 0.353, 95% CI = 0.237–0.525) were significantly different between centenarians and matched controls. The combination of B and V, such as B1B1-II (P < 0.001, OR = 0.128, 95% CI = 0.049–0.329), B1B1-IV (P < 0.001, OR = 0.115, 95% CI = 0.056–0.237), B1B2-VV (P < 0.05, OR = 0.534, 95% CI = 0.310–0.920), and B2B2-VV (P < 0.001, OR = 0.198, 95% CI = 0.086–0.453) have significant differences between centenarians and matched healthy individuals from Hainan.ConclusionOur results implied that allele B1B1 and VV, as well as the combination B1B1-II, B1B1-IV, B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan, south of China.