کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3455352 1596009 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of transplantation of BMMSCs on pathological change of gastric precancerous lesions of rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Effect of transplantation of BMMSCs on pathological change of gastric precancerous lesions of rats
چکیده انگلیسی

ObjectiveTo build the rat model of gastric precancerous lesions and discuss the effect of transplantation of mesenchymal stem cells (BMMSCs) on the pathological change.MethodsThe rat model of gastric precancerous lesions was built using N-methyl-N′-nitro-N′-nitrosoguanidine. After the intravenous transplantation of BMMSCs, the migration and colonization location was then observed, as well as its effect on the related factors of gastric precancerous lesions, including VEGF, IL-10 and IFN-γ.ResultsBMMSCs were mainly colonized in the gastric body and gastric antrum, which could be differentiated into the epithelial and interstitial cells. The expression of VEGF in the transplantation group and non-transplantation group was significantly higher than that in the control group (P < 0.05); while the expression of VEGF in the transplantation group was significantly higher than that in the non-transplantation group (t = 3.88, P < 0.001). The expression of serum IL-10 and IFN-γ in the transplantation group and non-transplantation group was significantly higher than that in the control group (P < 0.05), while the expression of IL-10 and IFN-γ in the transplantation group was significantly lower than that in the non-transplantation group (t = 3.03, P = 0.004; t = 3.80, P < 0.001).ConclusionsBMMSCs can be directionally differentiated into the epithelial and interstitial cells and can also regulate the related growth factors and inflammatory factors to reduce the injury of inflammation, relieve or reverse the process of gastric precancerous lesions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Medicine - Volume 8, Issue 12, December 2015, Pages 1060–1063
نویسندگان
, , , , ,