Meta analysis of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia

ObjectiveTo assess the relation between XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia.MethodsRelated studies of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia were collected through searching the Pubmed, Embase Library, SPRINGER, CNKI and CSSCI.ResultsAccording to the entry criteria, there were 8 case-control studies in the assessing system and there were 6 321 study cases, including 3 215 patients with lung cancer and 3 106 cases without cancers. Meta analysis results showed the combined OR value of the ratio of genotype Thr/Met+Met/Met and Thr/Thr was 1.03 (95%CI: 0.89–1.20) (P>0.05).ConclusionsXRCC3 Thr241Met polymorphism may not related to lung cancer susceptibility of populations in East Asia. Allele 241Met did not increase the risk of lung cancer.