Changes of TIZ expression in epithelial ovarian cancer cells

ObjectiveTo study the change of TIZ expression in epithelial ovarian cancer cells.MethodsHO8910 cells were transinfected with siRNA to inhibit the expression of TIZ. pcDNA3.1–TIZ vectors were combined to increase the TIZ expression level. The cell viability, colony forming efficiency and cycle distribution of HO8910, HO8910/NC, HO8910/pcDNA3.1–NC, HO8910/TIZ–573 and H08910/pcDNA3.1–TIZ were compared, and the invasion rate, migration rate and adhesion rate between 5 groups of cells were compared.ResultsCompared with those of HO8910, HO8910/NC and HO8910/pcDNA3.1–NC, the cell viability, colony forming efficiency and cell cycle distribution of HO8910/TIZ–573 were increased, while the indexes of H08910/pcDNA3.1–NC were decreased with statistical significant difference (P<0.05). There was no statistical significant difference in the invasion rate, migration rate and adhesion rate between 5 groups of cells (P>0.05).ConclusionsThe expression of TIZ can inhibit the proliferation of epithelial ovarian cancer cells.