کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3459531 1231172 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
False Human Immunodeficiency Virus Test Results Associated with Rheumatoid Factors in Rheumatoid Arthritis
ترجمه فارسی عنوان
نتایج بدست آمده از نتایج آزمایش ویروس نقص ایمنی بدن ناشی از عوامل روماتوئید در آرتریت روماتوئید
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی

ObjectiveTo investigate if immunological factors associated with rheumatoid arthritis (RA) affect the result of human immunodeficiency virus (HIV) screening by electrochemiluminescence immunoassay (ECLIA) and enzyme-linked immunosorbent assay (ELISA).Methods100 RA cases were enrolled from January 2012 to February 2013 into this study. HIV screening was conducted with ECLIA detecting both HIV-1 p24 antigen, HIV-1 and HIV-2 antibodies, with ELISA and colloidal gold method detecting HIV-1 and HIV-2 antibodies. The samples producing positive results were submitted to the Center for Disease Control for confirmation using Western blotting method. The antibody titers of rheumatoid factors (RF) including RF-IgG, RF-IgM, RF-IgA, and CCP-IgG were analyzed by ELISA.ResultsThe HIV positive-rate determined by ECLIA was significantly higher than that by ELISA and colloidal gold method (P<0.01). The false-positive rate of HIV screening was associated with antibody titers of RF-IgG, RF-IgM, RF-IgA, and CCP-IgG in RA (P<0.01).ConclusionImmunological factors, including RF and anti-CCP antibody, may influence the screening of HIV by ECLIA, producing false-positive result.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Medical Sciences Journal - Volume 29, Issue 2, June 2014, Pages 103-106