Treatment of Diabetes: A Clinical Update on Insulin Trials

The prevalence of diabetes, along with its accompanying long-term microvascular and macrovascular complications, continues to increase. Landmark studies of both type 1 and type 2 diabetes have provided the foundations on which to investigate improved treatment strategies for type 2 diabetes. Recent evidence suggests a new paradigm for treating type 2 diabetes that adds insulin earlier in the treatment process to maintain tight glycemic control. The newer insulin analogues in combination with oral antidiabetic agents provide a viable option for improving glycemic control and preventing or delaying the occurrence of complications.