کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3460117 1231218 2006 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Early intervention to achieve optimal outcomes in type 2 diabetes: A case presentation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Early intervention to achieve optimal outcomes in type 2 diabetes: A case presentation
چکیده انگلیسی

Type 2 diabetes mellitus (DM) is a progressive disease characterized by insulin resistance and impaired insulin secretion. To compensate for these metabolic dysfunctions, pancreatic β-cells begin to overproduce insulin; however, it is this compensatory mechanism that eventually results in β-cell exhaustion, impaired insulin secretion, and relative insulin deficiency. The metabolic abnormalities associated with diabetes also contribute to vascular dysfunction and an increased risk of coronary heart disease. Among patients with type 2 DM, cardiovascular disease, particularly macrovascular disease, is the primary cause of mortality, accounting for 55% of deaths. Management of the disease, therefore, must address all of the contributing factors, including a sedentary lifestyle and diet that contribute to overweight/obesity, and comorbidities such as hypertension and dyslipidemia. In this paper, we present a case study based on actual clinical experience to illustrate an evidence-based rationale for early and aggressive intervention for patients with type 2 DM, including lifestyle modification, oral antidiabetic agents, and insulin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Cornerstone - Volume 8, Supplement 2, 2006, Pages S6-S18