کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3461412 1231378 2008 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antimitochondrial Antibodies and Other Antibodies in Primary Biliary Cirrhosis: Diagnostic and Prognostic Value
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Antimitochondrial Antibodies and Other Antibodies in Primary Biliary Cirrhosis: Diagnostic and Prognostic Value
چکیده انگلیسی

Antimitochondrial antibodies (AMA) are the serologic cornerstone in the diagnosis of primary biliary cirrhosis (PBC), even if they are not detectable in a proportion of patients, notwithstanding the most sensitive and sophisticated technologies used. To fill in the serologic gap in AMA-negative PBC, there is sound evidence to consider antinuclear antibody (ANA) patterns, such as anti–multiple nuclear dots and anti–membranous/rim-like, as PBC-specific surrogate hallmarks of the disease, and their detection can be considered virtually diagnostic. Furthermore, particular ANA specificities, such as anti-gp210, anti-p62, anticentromere antibodies, and anti-dsDNA, may provide additional diagnostic and prognostic information.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinics in Liver Disease - Volume 12, Issue 2, May 2008, Pages 261–276
نویسندگان
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