کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3461487 | 1231382 | 2007 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Causality Assessment of Drug-Induced Hepatotoxicity: Promises and Pitfalls
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Drug-induced liver injury is the leading cause of acute liver failure in the United States, but the ability to ascribe hepatic injury confidently to a specific drug remains a challenging and often difficult pursuit. This article explores the ongoing challenges inherent in what is currently a clinical process of elimination made in the attempt of assigning causality in drug-induced liver injury. In particular, it points out the shortcomings and pitfalls that often limit the applicability of the causality-assessment methodologies currently in use.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinics in Liver Disease - Volume 11, Issue 3, August 2007, Pages 477–505
Journal: Clinics in Liver Disease - Volume 11, Issue 3, August 2007, Pages 477–505
نویسندگان
Max A. Shapiro, James H. Lewis,