کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3463019 1231527 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bayesian sample size determination under hypothesis tests
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Bayesian sample size determination under hypothesis tests
چکیده انگلیسی

We develop a Bayesian approach for calculating sample sizes for clinical trials under the framework of hypothesis tests. We extend the work of Weiss (The Statistician 1997; 46: 185-191) to include composite distributions for the treatment effect and the variance of the data within the null and alternative hypotheses. We select sample sizes using the Bayes factor and the averaged type I error and type II error defined by Weiss (The Statistician 1997; 46: 185-191). Our approach allows the uncertainty inherent in eliciting prior information for both the treatment effect and the variance and permits informative prior information for unknown quantities through the hypothesis specification. We illustrate our method through a real data example from a clinical trial for treatment of multiple sclerosis and from the cerclage trial for preterm birth prevention in high-risk women.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contemporary Clinical Trials - Volume 32, Issue 3, May 2011, Pages 393–398
نویسندگان
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