کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3463025 1231527 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of statin therapy on disease progression in pediatric ADPKD: Design and baseline characteristics of participants
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Effect of statin therapy on disease progression in pediatric ADPKD: Design and baseline characteristics of participants
چکیده انگلیسی

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney condition and is associated with important renal and cardiovascular manifestations in childhood. Renal cystic disease can be documented in some cases as early as in utero. Early intervention is critical if the long-term complications of this condition, including end-stage renal disease, are to be ameliorated. Here we describe our ongoing randomized double-blind placebo-controlled phase III clinical trial to assess the effect of pravastatin treatment on renal and cardiovascular disease progression in 107 children and young adults age 8–22 years with ADPKD who are receiving the angiotensin converting enzyme inhibitor lisinopril. Baseline demographic and laboratory data are provided. Results of this study could markedly impact the standard of care for evaluation and treatment of ADPKD in this population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contemporary Clinical Trials - Volume 32, Issue 3, May 2011, Pages 437–445
نویسندگان
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