کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3466566 | 1596587 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Targeting IL-1β in disease; the expanding role of NLRP3 inflammasome Targeting IL-1β in disease; the expanding role of NLRP3 inflammasome](/preview/png/3466566.png)
NLRP3 inflammasome activation and IL-1β secretion have recently emerged as a central mechanism in the pathogenesis of disease. Genetically defined syndromes like cryopyrin-associated periodic syndromes (CAPS, cryopyrinopathies) and familial Mediterranean fever (FMF) or diseases associated with NLRP3 activation by danger signals like gout, pseudogout, Alzheimer's disease or type 2 diabetes are included in this group of diseases. The contribution of anakinra, a recombinant, nonglycosylated human IL-1 receptor antagonist, in both the identification and treatment of such syndromes was considerable. Recently, rilonacept, a long-acting IL-1 receptor fusion protein, and canakinumab, a fully humanized anti-IL-1β monoclonal antibody, have been developed, with the intention to further extent IL-1β inhibition treatment strategies to a broader spectrum of disorders beyond the characterized autoinflammatory syndromes, offering a more favorable administration profile. On the other hand, the developed caspase-1 inhibitors, even though effective in experimental models, were not proven efficient in the treatment of inflammatory diseases.
Journal: European Journal of Internal Medicine - Volume 21, Issue 3, June 2010, Pages 157–163