کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3473891 1233103 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Heart Failure with Preserved Ejection Fraction: Hypertension, Diabetes, Obesity/Sleep Apnea, and Hypertrophic and Infiltrative Cardiomyopathy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Heart Failure with Preserved Ejection Fraction: Hypertension, Diabetes, Obesity/Sleep Apnea, and Hypertrophic and Infiltrative Cardiomyopathy
چکیده انگلیسی

The detailed pathophysiology of heart failure with preserved ejection fraction (HF-PEF) remains an area of active research and controversy; however, abnormalities of diastolic function are generally believed to play an important role. Most commonly, diastolic dysfunction occurs as a consequence of myocyte hypertrophy, endomyocardial fibrosis, and abnormalities of intracellular calcium handling that are related to normal myocardial aging and accelerated by comorbidities such as hypertension, diabetes, coronary artery disease, and obesity. In this article, three fundamental risk factors are considered for “secondary” diastolic dysfunction and HF—hypertension, diabetes, and obesity—with an emphasis on the clinical epidemiology, pathophysiologic mechanisms, and treatment implications of each. The article concludes with a brief discussion of “primary” diastolic HF due to infiltrative or restrictive cardiomyopathies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Failure Clinics - Volume 4, Issue 1, January 2008, Pages 87–97
نویسندگان
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