Value of serum OPN levels in patients with acute cerebral hemorrhage for assessment of nerve function impairment

ObjectiveTo study the value of serum OPN levels in patients with acute cerebral hemorrhage for assessment of neurological impairment.MethodsA total of 48 patients with cerebral hemorrhage admitted to the Emergency Department of our hospital from April 2014 to August 2015 were selected as the cerebral hemorrhage group, and 50 cases who took health examination were selected as the control group. Then, their clinical data were collected and the contents of OPN, S-100β, NSE, SOD, T-AOC and MDA were detected.ResultsThe contents of serum OPN [(24.52 ± 2.85) vs. (10.38 ± 1.25) pg/mL], S-100β [(1.77 ± 0.20) vs. (0.59 ± 0.07) pg/mL] and NSE [(24.52 ± 2.85) vs. (10.38 ± 1.25) pg/mL] in the cerebral hemorrhage group were significantly higher than those of the control group, while its SOD [(42.31 ± 5.45) vs. (67.65 ± 7.26) IU/mL] and T-AOC [(12.16 ± 1.42) vs. (20.35 ± 2.35) IU/mL] were all distinctly lower than those of the control group. The greater the amount of hemorrhage was, the more the contents of OPN [(5.75 ± 0.67) vs. (7.92 ± 0.91) vs. (10.36 ± 1.16) ng/mL], S-100β [(1.03 ± 0.12) vs. (1.79 ± 0.20) vs. (2.85 ± 0.30) pg/mL], NSE [(17.86 ± 2.14) vs. (23.94 ± 2.61) vs. (30.14 ± 3.48) pg/mL], MDA [(4.03 ± 0.51) vs. (6.18 ± 0.81) vs. (9.59 ± 1.05) nmol/mL] were and the less the contents of SOD [(52.44 ± 5.94) vs. (41.39 ± 5.26) vs. (25.52 ± 3.12) IU/mL] and T-AOC [(16.59 ± 1.83) vs. (13.04 ± 1.63) vs. (8.39 ± 0.92) IU/mL] became. The contents of serum OPN [(13.23 ± 1.63) vs. (6.95 ± 0.81) ng/mL], S-100β [(3.24 ± 0.52) vs. (0.91 ± 0.10) pg/mL], NSE [(41.32 ± 5.14) vs. (16.61 ± 1.89) pg/mL] and MDA [(11.18 ± 1.26) vs. (4.28 ± 0.54) nmol/mL] in patients with early deterioration were obviously higher than those in patients without early deterioration, while their SOD [(15.25 ± 1.79) vs. (40.59 ± 5.33) IU/mL] and T-AOC [(5.25 ± 0.77) vs. (16.25 ± 1.92) IU/mL] contents were all evidently lower. The content of serum OPN was positively associated with S-100β, NSE and MDA, but negatively correlated with SOD and T-AOC.ConclusionsThe level of serum OPN in patients with acute cerebral hemorrhage increased significantly. The level of serum OPN could estimate the bleeding volume and the severity of nerve function impairment for patients with acute cerebral hemorrhage.